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    ROS1

    • ROS1 is a receptor tyrosine kinase of the insulin receptor family, similar to ALK.

     

    • ROS1 gene rearrangements are more likely found in younger patients (<50 years) and light/never smokers and associated with adenocarcinoma.1

     

    • ROS1 has been included in the 2013 NCCN guidelines as a relevant biomarker in NSCLC, including showing response to ALK Inhibitor therapy.2

     

    References:

    1. Bergethon K, Shaw AT, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012:30:863-870.

    2. NCCN Guidelines Version 2.2013

    This test was developed by and its performance characteristics determined by PersonalizeDx. It has not been cleared or approved by the U.S. Food and Drug Administration. PersonalizeDx is a CLIA-accredited laboratory CLIA ID #05D2001811. This test is used for clinical purposes. The clinical validity of the test has been established based upon review of relevant literature. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity testing.